| Autor: |
Jacoby RF; Section of Gastroenterology, University of Wisconsin Medical School, Madison 53792., Hohman C, Marshall DJ, Frick TJ, Schlack S, Broda M, Smutko J, Elliott RW |
| Jazyk: |
angličtina |
| Zdroj: |
Genomics [Genomics] 1994 Jul 15; Vol. 22 (2), pp. 381-7. |
| DOI: |
10.1006/geno.1994.1399 |
| Abstrakt: |
Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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