| Autor: |
Yohn JJ; Department of Dermatology, University of Colorado School of Medicine, Denver 80262., Smith C, Stevens T, Morelli JG, Shurnas LR, Walchak SJ, Hoffman TA, Kelley KK, Escobedo-Morse A, Yanagisawa M, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1994 Dec 30; Vol. 1224 (3), pp. 454-8. |
| DOI: |
10.1016/0167-4889(94)90282-8 |
| Abstrakt: |
We investigated endothelin-1 (ET-1) receptor expression on normal human keratinocytes (HK). We show that HK express the ETB receptor isoform and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; however, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-conditioned medium. We propose that HK ET-1 receptors function in autocrine regulation of ET-1 secretion. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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