| Autor: |
Dzenis IG, Brykova EK, Zaretskaia NV, Polesterov IuA, Bakharev VA, Fanchenko ND |
| Jazyk: |
ruština |
| Zdroj: |
Akusherstvo i ginekologiia [Akush Ginekol (Mosk)] 1995 (2), pp. 23-6. |
| Abstrakt: |
A total of 103 samples of amniotic fluid obtained by transabdominal amniocentesis were examined, 52 of these from women at a high risk of giving birth to children with congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency and 30 ones with fetuses with different neural tube malformations. 17-Hydroxyprogesterone was found to be a reliable marker indicating the disease in fetuses from the group at risk of hereditary 21-OH deficiency. This marker can be effectively used as early as in the 1 gestation trimester. Fetal CNS defects are associated with hypofunction of the adrenal cortex in the II gestation trimester, observed in 60-63% of cases with hydrocephalus, anencephaly, or microcephaly. Since the function of fetal adrenals is of paramount importance for the development and maturation of a fetus, it should be examined in case of developmental defects of the neural tube, in order to predict the effect of prenatal treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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