| Autor: |
Angelos S; Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, USA., Valberg SJ, Smith BP, McQuarrie PS, Shanske S, Tsujino S, DiMauro S, Cardinet GH 3rd |
| Jazyk: |
angličtina |
| Zdroj: |
Muscle & nerve [Muscle Nerve] 1995 Jul; Vol. 18 (7), pp. 736-40. |
| DOI: |
10.1002/mus.880180710 |
| Abstrakt: |
A Charolais calf presented to the Veterinary Medical Teaching Hospital with a history of recumbency following forced exercise. The calf was unable to stand, and had severe rhabdomyolysis, dehydration, and electrolyte imbalance. Blood selenium concentrations were within normal limits. A complete absence of histochemical staining for phosphorylase was apparent in muscle biopsies. Five other animals in the herd also had exercise intolerance and had a complete absence of phosphorylase staining in muscle biopsies. Biochemical analyses confirmed a deficiency of myophosphorylase (range 0-0.3 mumol/g per minute: normals 15-27) with normal to slightly elevated muscle glycogen concentrations. Pedigrees from all affected animals showed a common ancestor on the sire's and dam's side of each phosphorylase-deficient animal, suggesting an autosomal recessive transmission. Although myophosphorylase deficiency was described in humans (McArdle's disease) over 40 years ago, these cattle represent the first animal model for this disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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