| Autor: |
Maurin N; Medical Clinic II, University Hospital Aachen, Germany., Fitzner S, Fritz H, Gladziwa U, H agel J, Stefanidis I |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical nephrology [Clin Nephrol] 1995 Mar; Vol. 43 (3), pp. 196-200. |
| Abstrakt: |
Twenty chronic hemodialysis patients with renal anemia (hematocrit < 25%) received recombinant human erythropoietin (40 IU/kg body weight 3 x weekly) intravenously after each dialysis. Prior to and at 4, 8 and 12 weeks after commencement of erythropoietin therapy, hematocrit together with hemostasis and microhemolysis parameters were determined. There were significant increases in hematocrit, platelet count and platelet retention, but a significant fall in the initial clearly prolonged bleeding time. Free plasma hemoglobin likewise increased. Conversely, lactate dehydrogenase, prothrombin time, fibrinogen, antithrombin III activity, protein C activity and protein S concentration were all unaltered. The positive effect on bleeding time and platelet retention is most probably caused by an increase in adenosine diphosphate due to the hematocrit-dependent rise in the blood shear stress via physiologic microhemolysis (raised free plasma hemoglobin). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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