| Autor: |
Egorov IK; Jackson Laboratory, Bar Harbor, Maine 04609, USA., Nickonenko BV |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in immunology [Crit Rev Immunol] 1994; Vol. 14 (3-4), pp. 337-53. |
| DOI: |
10.1615/critrevimmunol.v14.i3-4.60 |
| Abstrakt: |
In this review, new data are interpreted that provide some answers to the question of why the immune system fails to respond to metastatic cancers. A function such as an element of the immune response is expected to be under the control of a gene. To find a gene, a mutant is required. Complex screens have been designed and used to detect mouse mutants resisting spread of transplantable tumors (in a spontaneous metastasis assay). Curiously, both mutants with increased and decreased resistance to spread of the tumor have been found. S-27 is a strongly resistant mutant linked to MHC; this mutation also affected some responses to Mycobacterium tuberculosis infection. A long sought link between malignant transformation and vaccination against mycobacterial diseases is discovered in this mutant. A search for a molecule responsible for effects of the S-27 mutation resulted in an unexpected finding. The S-27 mutant carries complex nucleotide alterations at the junction between the signal sequence and the sequences coding for the mature MHC class II A beta polypeptide chain. Antigen recognition region of the A beta molecule is not affected by this mutation. Some concepts developed during the course of this study are illustrated in Figures 1 to 4. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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