| Autor: |
Berry SM; Division of Maternal Fetal Medicine, Wayne State University, Detroit, Michigan, USA., Lecolier B, Smith RS, Bercau G, Dombrowski MP, Puder KS, Kithier K, Bidat L, Johnson MP, Cotton DB |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1995 May 20; Vol. 345 (8960), pp. 1277-8. |
| DOI: |
10.1016/s0140-6736(95)90928-1 |
| Abstrakt: |
When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography. Serum beta 2-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum beta 2-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A beta 2-microglobulin above a 5.6 mg/L cut-off gave cross-validated sensitivity of 80.0%, specificity of 98.6%, a positive predictive value of 88.9%, and a negative predictive value of 97.1% for our cohort study. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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