Hypertension and lens opacities from the Beaver Dam Eye Study.

Autor: Klein BE; Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA., Klein R, Jensen SC, Linton KL
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 1995 May; Vol. 119 (5), pp. 640-6.
DOI: 10.1016/s0002-9394(14)70223-5
Abstrakt: Purpose: To examine the relationship between hypertension and lens opacities, and the use of antihypertensive agents.
Methods: A total of 4,926 adults, 43 to 84 years of age, living in Beaver Dam, Wisconsin, at the time of a private census, were invited to participate in a study that included a medical interview and an examination that included ocular photography. All study procedures and photographic grading were done according to standard protocols.
Results: According to analysis with the Liang-Zeger multiple logistic regression model, people with hypertension were more likely to have posterior subcapsular opacities than people without hypertension (odds ratio, 1.39; 95% confidence interval, 1.05, 1.84). Specific medications for hypertension did not meaningfully affect the risk. Hypertension was associated with increased risk in both those with and without diabetes.
Conclusions: Hypertension is associated with increased risk of posterior subcapsular opacities. The pathophysiologic mechanisms that may explain the relationship are unknown. Incidence data will give a better indication of temporal relationship between hypertension, medications to lower blood pressure, and lens opacities.
Databáze: MEDLINE
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