| Autor: |
Alkema MJ; Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam., van der Lugt NM, Bobeldijk RC, Berns A, van Lohuizen M |
| Jazyk: |
angličtina |
| Zdroj: |
Nature [Nature] 1995 Apr 20; Vol. 374 (6524), pp. 724-7. |
| DOI: |
10.1038/374724a0 |
| Abstrakt: |
The oncogene bmi-1, which was originally found to be involved in B- and T-cell lymphoma formation encodes a protein with a domain of homology to the Drosophila protein Posterior sex combs (Psc) and its relative Suppressor 2 of Zeste (Su(z)2) (refs 4 and 5). Psc is a member of the Polycomb-group gene family, which is required to maintain the repression of homeotic genes that regulate the identities of Drosophila segments. The possibility that bmi-1 may play a similar role in vertebrates was suggested by our previous finding that mice lacking the bmi-1 gene show posterior transformations of the axial skeleton. Here we report that transgenic mice overexpressing Bmi-1 protein show the opposite phenotype, namely a dose-dependent anterior transformation of vertebral identity. The anterior expression boundary of the Hoxc-5 gene is shifted in the posterior direction, indicating that Bmi-1 is involved in the repression of Hox genes. We propose that Bmi-1 is a member of a vertebrate Polycomb complex that regulates segmental identity by repressing Hox genes throughout development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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