| Autor: |
Colman-Saizarbitoria T; Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907., Gu ZM, McLaughlin JL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 1994 Dec; Vol. 57 (12), pp. 1661-9. |
| DOI: |
10.1021/np50114a007 |
| Abstrakt: |
Xylopien [1] and xylomatenin [2], two new bioactive monotetrahydrofuran Annonaceous acetogenins, have been isolated from an EtOH extract of the bark of Xylopia aromatica, using bioactivity-directed fractionation employing lethality to brine shrimp. These new compounds each have a double bond in the hydrocarbon chain and have been identified as C-23, C-24 dehydro analogs of xylopiacin and xylomaticin. Their structures were elucidated by spectral analyses of the parent compounds and/or simple chemical derivatives. Their absolute stereochemistries have been established by 1H- and 2D nmr experiments utilizing the production of Mosher esters. These acetogenins showed cytotoxic potencies superior to adriamycin against three human solid tumor cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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