| Abstrakt: |
Changes in mean blood pressure (MBP), heart rate (HR), diuresis, natriuresis and kaliuresis, which had been evoked by intravenous bolus administration of the synthetic atrial natriuretic peptides (ANP) ANP (99-126), ANP (103-126), ANP (103-125), and ANP (103-123) in doses of 10 and 60 micrograms/kg each, were studied during 2% body weight volume expansion by intraarterial injections of 0.9% NaCl in awake rats. All the ANP analogues were indicated to decrease MBP and induce differential changes in HR. All the ANP analogues, except ANP (103-123), increased diuresis and natriuresis in the first 30 min of the experiment. |
