Paclitaxel (Taxol) concentrations in brain tumor tissue.
| Autor: | Heimans JJ; Department of Neurology, Free University Hospital, Amsterdam, The Netherlands., Vermorken JB, Wolbers JG, Eeltink CM, Meijer OW, Taphoorn MJ, Beijnen JH |
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| Jazyk: | angličtina |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 1994 Dec; Vol. 5 (10), pp. 951-3. |
| DOI: | 10.1093/oxfordjournals.annonc.a058736 |
| Abstrakt: | Background: Paclitaxel (Taxol) is a novel chemotherapeutic agent, active against a variety of tumors. It is not known whether the drug penetrates brain tumor tissue. Patients and Methods: Three patients with a recurrent glioma received paclitaxel (175 mg/m2) in a 3-hour i.v. infusion prior to surgery. Paclitaxel concentrations were measured in the tumor tissue, cerebrospinal fluid, cyst fluid, plasma and, in one patient, normal brain tissue. Results: Tumor tissue concentrations were in the therapeutic range in all three patients. Brain tissue concentration, however, was below the detection limit of the trial. Conclusions: These findings suggest that paclitaxel may have a place in brain tumor therapy. The low concentration in normal brain tissue, as observed in one patient, may suggest, however, that the drug does not cross the intact bloodbrain barrier. |
| Databáze: | MEDLINE |
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