| Autor: |
Podkuĭko VN, Vorob'ev AA, Krasnianskiĭ VP, Patrikeev GT, Mikhaĭlov VV, Dorokhina TV, Makhlaĭ AA, Dykanov GA |
| Jazyk: |
ruština |
| Zdroj: |
Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 1993 (2), pp. 39-44. |
| Abstrakt: |
Oral and dermal administrations of vaccinia virus into rabbits, guinea pigs, and monkeys demonstrated a milder (without homeostasis disturbance) course of the vaccinal process with oral immunization, intensive immunity forming in minimal sensitization of the body was compared with dermal one. The results of revaccination in adults with oral smallpox vaccine and primary immunization in Ethiopia showed that oral immunization with vaccinia virus was safe, effective and lowly reactogenic. The comparative study of the preparation in remote revaccination (5 or more years later) proved its advantage over dermal vaccine. It consists in ecological safety (vaccinia virus excretion into the environment during 1 and 11 days, respectively, by 10-fold concentration reduction), reactogenicity (5 and 33% of common reactions, respectively) in the same immunogenicity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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