| Autor: |
White-Scharf ME; Repligen Corporation, Cambridge, Massachusetts 02139., Potts BJ, Smith LM, Sokolowski KA, Rusche JR, Silver S |
| Jazyk: |
angličtina |
| Zdroj: |
Virology [Virology] 1993 Jan; Vol. 192 (1), pp. 197-206. |
| DOI: |
10.1006/viro.1993.1022 |
| Abstrakt: |
The third hypervariable region (V3) of the HIV-1 envelope gp120 protein contains the principal neutralizing domain. Most neutralizing antibodies directed toward this region are very type-specific. Conserved sequences do exist within this region, however, and may prove useful in developing vaccines and therapeutic monoclonal antibodies (MABs) capable of targeting diverse HIV-1 isolates. We have used synthetic peptides containing conserved V3 sequences as immunogens to produce a panel of neutralizing MABs. The characterization of these MABs is described here. In addition, a series of in vitro assays has been developed that may be useful in predicting the neutralization potential of individual antibodies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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