| Autor: |
Madrigal-Bujaidar E; Laboratorio de Genética, Escuela Nacional de Ciencias Biológicas, I.P.N. Carpio y Plan de Ayala, México, D.F., Cadena SR, Trujillo-Valdés VM, Cassani M |
| Jazyk: |
angličtina |
| Zdroj: |
Mutation research [Mutat Res] 1993 Jul; Vol. 300 (2), pp. 135-40. |
| DOI: |
10.1016/0165-1218(93)90131-v |
| Abstrakt: |
Metrifonate is a drug widely used to cure several helminthiases in man including cysticercosis. In this study we determine its capacity to induce SCEs in vivo and in vitro using the fluorescence-plus-Giemsa technique. In the human lymphocyte system we tested 10, 20, 30, 40, 50 and 60 micrograms/ml added at 24 h of culture with a duration of 72 h. The results showed a SCE inducing effect with the exception of the first tested dose (10 micrograms/ml), but without a dose-response expression. A cell cycle progression delay was seen with the three highest dosages. In the mouse bone marrow we tested 30, 60 and 120 mg/kg in a 24-h experiment, and the results indicated an SCE increase only with the highest dose. No modification of the cell proliferation kinetics was observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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