| Autor: |
Snater E; Academisch Ziekenhuis Nijmegen, The Netherlands., Janssen EA, van der Valk PG, van de Kerkhof PC |
| Jazyk: |
angličtina |
| Zdroj: |
The British journal of dermatology [Br J Dermatol] 1995 Jun; Vol. 132 (6), pp. 908-12. |
| DOI: |
10.1111/j.1365-2133.1995.tb16947.x |
| Abstrakt: |
Dithranol is established as a very successful treatment for psoriasis. Its main disadvantages are irritation and staining at sites of application. The aim of the present study was to elucidate further the mechanism of dithranol-induced irritation, in particular to what extent this is related to an impairment of the skin barrier. Dithranol 3% in cream, paste and petrolatum was applied to the forearm skin of 20 volunteers and left in situ for 1 h. Transepidermal water loss (TEWL) was measured during a period of 2 weeks following dithranol application. In addition, a visual scoring system and colorimetry were used to assess erythema. The study showed conclusively that TEWL was not affected by the application of dithranol, even though pronounced erythema occurred. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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