| Autor: |
Pier AC; Department of Veterinary Sciences, University of Wyoming, Laramie 82071, USA., Hodges AB, Lauze JM, Raisbeck M |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology [J Med Vet Mycol] 1995 Mar-Apr; Vol. 33 (2), pp. 93-7. |
| Abstrakt: |
An inactivated, broad-spectrum dermatophyte vaccine was used to produce an active immunity in guinea-pigs against Microsporum canis. None of the vaccinates developed infection from a contact exposure challenge that produced clinical infections in 70% of the unvaccinated controls. Infection with M. canis induced antibody titres (ELISA) and delayed cutaneous hypersensitivity (DCH) reactions to itself as well as cross-reacting titres to Trichophyton equinum and T. mentagrophytes and DCH reactions to T. mentagrophytes; however vaccinated animals developed significantly higher antibody titres and DCH responses to all of these antigens than did non-vaccinated animals which had been infected or exposed. Rabbits hyperimmunized with culture filtrate antigens to single dermatophyte agents (M. canis, M. gypseum, T. equinum, and T. mentagrophytes) developed positive inter-species and inter-generic DCH cross-reactions to a battery of six skin test antigens (M. canis, M. gypseum, M. equinum, T. equinum, T. mentagrophytes var. mentagrophytes and T. verrucosum). Guinea-pigs vaccinated with a T. equinum vaccine had increased resistance to M. canis infection than did non-vaccinated controls. These findings support clinical observations which suggest establishment of a broad-based immunity in animals following infection with a single dermatophyte. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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