| Autor: |
Le Jambre LF; C.S.I.R.O. Division of Animal Health, Pastoral Research Laboratory, Armidale, N.S.W., Australia., Gill JH, Lenane IJ, Lacey E |
| Jazyk: |
angličtina |
| Zdroj: |
International journal for parasitology [Int J Parasitol] 1995 Jun; Vol. 25 (6), pp. 691-8. |
| DOI: |
10.1016/0020-7519(94)00200-8 |
| Abstrakt: |
A strain of Haemonchus contortus (CAVR) isolated in Australia was found to be resistant to ivermectin (IVM) with 0.4 mg kg-1 of the anthelmintic failing to significantly reduce worm burdens. Resistance to IVM was sex-influenced in the CAVR strain with adult males showing a greater sensitivity to IVM. Cross resistance to moxidectin was evident with approximately 15% of the population surviving a dose of 0.1 mg kg-1. The free-living stages of the CAVR isolate had a reduced sensitivity to avermectin (AVM) inhibition of development and motility. Similar structure-activity patterns and resistance factors were obtained for a series of related AVMs as inhibitors of larval development and L3 motility in CAVR and White River II, an IVM-resistant H. contortus isolate from South Africa. Further, both isolates were found to be 3 times more sensitive to paraherquamide than a susceptible H. contortus isolate. This suggest that the same resistance mechanism is operating in both isolates. The CAVR strain is susceptible to the benzimidazoles, levamisole and closantel. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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