| Autor: |
Gessler NN, Fedotcheva NI, Foĭgel' AG, Alekseeva NV, Kondrashova MN, Bykhovskiĭ VIa |
| Jazyk: |
ruština |
| Zdroj: |
Biokhimiia (Moscow, Russia) [Biokhimiia] 1995 Jun; Vol. 60 (6), pp. 981-6. |
| Abstrakt: |
Changes in the activity of monoamine oxidase (MAO-B) in liver homogenates and mitochondria from normal and vitamin B12-deficient rats have been studied in various functional states of the mitochondria. Preincubation of liver preparation at 32 degrees C increased the MAO affinity for benzylamine in samples of normal (but not vitamin B12-deficient rats). Succinate added to the incubation medium decreased Km and increased Vmax in both normal and vitamin B12-deficient animals. A correlation was found between the decline of MAO-B activity under vitamin B12 deficiency, deceleration of succinate oxidation and reduction of the transmembrane potential. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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