| Autor: |
van Roozendaal CE; Department of Medical Oncology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands., Klijn JG, van Ooijen B, Claassen C, Eggermont AM, Henzen-Logmans SC, Foekens JA |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular and cellular endocrinology [Mol Cell Endocrinol] 1995 Apr 28; Vol. 111 (1), pp. 1-6. |
| DOI: |
10.1016/0303-7207(95)03539-j |
| Abstrakt: |
Transforming growth factor beta (TGF-beta) is a hormonally regulated growth inhibitor with autocrine and/or paracrine functions in human breast cancer. In vivo, enhanced immunohistochemical staining of extracellular TGF-beta 1 has been detected around stromal fibroblasts in response to the antiestrogen treatment. We have investigated the effects of tamoxifen on the production of TGF-beta by primary human breast fibroblast cultures in serum-free medium. Highly variable levels of mainly latent TGF-beta 1 were detected in conditioned media from both tumor and normal tissue derived fibroblasts. Hydroxy-tamoxifen was shown to increase latent TGF-beta 1 secretion in three of the eight tumor tissue-derived fibroblast cultures. Such effect of hydroxy-tamoxifen was not observed in fibroblast cultures established from normal adjacent breast tissue. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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