| Autor: |
van de Velde MJ; Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands., Engels F, Henricks PA, Bloemen PG, Nijkamp FP |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1995 Aug 07; Vol. 369 (2-3), pp. 301-4. |
| DOI: |
10.1016/0014-5793(95)00773-3 |
| Abstrakt: |
The effect of the linoleic acid metabolite 13-hydroxyoctadecadienoic acid human polymorphonuclear leukocytes (PMNs) was investigated by measuring the expression of CD11b and CD67 on the plasma membrane. 13-HODE (5 microM) by itself induced degranulation of PMNs, but to a lesser extent as compared to PAF and fMLP. In addition, 13-HODE was found to inhibit the PAF-induced degranulation whereas an additive effect on the fMLP-induced PMNs degranulation was observed. These results indicate that 13-HODE can play a modulatory role in degranulation of PMNs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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