| Autor: |
Gewert DR; Department of Cell Biology, Wellcome Foundation, Ltd., Beckenham, Kent, England., Sharp NA, Barber KA, Cooper H, Tucker D, Lewis AP, Thursz M, Crowe JS |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 1995 May; Vol. 15 (5), pp. 403-6. |
| DOI: |
10.1089/jir.1995.15.403 |
| Abstrakt: |
We have analyzed human donor DNA for the presence of sequences corresponding to allelic variants of the IFN-alpha 2 locus. Using both restriction enzyme digestion of PCR-amplified fragments and sequence analysis of these fragments, we have identified the three reported allelic variants, IFN-alpha 2a, IFN-alpha 2b, and IFN-alpha 2c, in genomic DNA derived from donors of African or Afro-Caribbean origin. This is the first report of the IFN-alpha 2a and IFN-alpha 2c alleles occurring in human donor DNA and supports the view that these are variants of the predominant IFN-alpha 2b allele rather than arising from mutations occurring in cultured cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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