| Autor: |
Wang S; Molecular Epidemiology and Disease Indicators Branch, NIDR, Bethesda, Maryland 20892, USA., Sun CE, Walczak CA, Ziegle JS, Kipps BR, Goldin LR, Diehl SR |
| Jazyk: |
angličtina |
| Zdroj: |
Nature genetics [Nat Genet] 1995 May; Vol. 10 (1), pp. 41-6. |
| DOI: |
10.1038/ng0595-41 |
| Abstrakt: |
We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided results (P = 3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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