| Autor: |
Gu M; Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo 14214, USA., Haraszthy GG, Collins AR, Bergey EJ |
| Jazyk: |
angličtina |
| Zdroj: |
Oral microbiology and immunology [Oral Microbiol Immunol] 1995 Feb; Vol. 10 (1), pp. 54-9. |
| DOI: |
10.1111/j.1399-302x.1995.tb00118.x |
| Abstrakt: |
Salivary proteins play an important role in the maintenance of the oral ecology. Previous studies have indicated that human submandibular-sublingual and parotid salivas can selectively suppress the in vitro infectivity of herpes simplex virus 1. The purpose of this study was to identify the salivary components in human submandibular-sublingual saliva that modulate in vitro infectivity. Assessment of the interaction of viral particles with salivary components was accomplished using an in vitro solid-phase assay. These experiments revealed that herpes simplex virus particles selectively interact with the members of the salivary proline-rich protein and cystatin families. Subsequent yield reduction assays demonstrated the ability of proline-rich proteins and salivary cystatins to inhibit the viral replication, with basic proline-rich peptides being more effective. Subsequent assays suggest that basic proline-rich peptides reduced the virus titer by interfering with penetration and/or cellular processing of virus within the target cell. Collectively, these results further suggest that salivary proteins have an important role in the host defense mechanism against recurrent herpesvirus infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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