| Autor: |
Tiong SY; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Nash D, Bender W |
| Jazyk: |
angličtina |
| Zdroj: |
Development (Cambridge, England) [Development] 1995 Jun; Vol. 121 (6), pp. 1649-56. |
| DOI: |
10.1242/dev.121.6.1649 |
| Abstrakt: |
The wing imaginal disc is subdivided into a dorsal and a ventral compartments. A new dominant homeotic mutation, Dorsal wing1 (Dlw1), transforms ventral into dorsal compartment in heterozygotes. This phenotype is similar to one of the dominant phenotypes of Polycomb (Pc) mutants. In Pc Dlw+/Pc+ Dlw1 double mutants, the transformation is greatly enhanced. The recessive phenotype of Dlw1 is the opposite to the dominant phenotype. Dlw1/Dlw1 somatic clones induced at any larval stage differentiate only ventral pattern on both wing surfaces. This effect is one of the somatic clone phenotypes of trithorax (trx) lethals. A similar dorsal-to-ventral transformation is observed in Pc Dlw/Dlw clones. Dlw1/Dlw1 clones have no effect elsewhere, except in the dorsal notum, which may differentiate extra macrochaetes. We propose that: (1) Dlw+ is required for the specification of dorsal compartment; (2) some genes of the Polycomb group act as negative regulators of Dlw+, while some genes of the trithorax group act as positive regulators. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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