| Autor: |
Ginjaar IB; Department of Anatomy and Embryology, Academic Medical Centre, University of Amsterdam, The Netherlands., Virágh S, Markman MW, van Ommen GJ, Moorman AF |
| Jazyk: |
angličtina |
| Zdroj: |
Microscopy research and technique [Microsc Res Tech] 1995 Apr 15; Vol. 30 (6), pp. 458-68. |
| DOI: |
10.1002/jemt.1070300603 |
| Abstrakt: |
Duchenne muscular dystrophy (DMD) is frequently associated with myocardial involvement. Dystrophin, the DMD protein, is found at the plasmamembrane of striated muscle fibers. Although dystrophin is missing in most or all muscle fibers of DMD patients, cardiac muscle is not as severely affected as skeletal muscle. Therefore it is of great importance to study the expression of dystrophin in normal cardiac muscle. We performed immunohistochemical studies and examined cardiac muscle of fetuses of 8 to 13 weeks of development on dystrophin expression. At these stages dystrophin is observed in the myocytes of the developing ventricular conduction system and in the atrial cardiomyocytes. Dystrophin was absent from the heart of a 12-week-old DMD fetus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text