| Autor: |
Cabrera ME; Hospital del Salvador, Departamento de Medicina, Facultad de Medicina, Universidad de Chile., Labra S, Andrade W, Ossandón E, Barriga F |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Revista medica de Chile [Rev Med Chil] 1994 Sep; Vol. 122 (9), pp. 1052-5. |
| Abstrakt: |
We present the clinical and laboratory features of 2 patients with B prolymphocytic leukemia. Both are females of the fifth and seventh decade of life. One had the classical clinical picture of massive splenomegaly and a high white cell count, with characteristic prolymphocytes, and the other was asymptomatic, with a low white cell count. The cells were positive to B cell lineage reagents with strong surface immunoglobuline (Ig) and unreactive to T cell antibodies. Analysis of Ig genes at the DNA level demonstrated that both cases had heavy-chain gene rearrangements, confirming the B-cell origin. These are the first patients of prolymphocytic leukemia described in Chile. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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