Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women.
| Autor: | Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA., Weiss NS, Voigt LF, Daling JR, Habel LA, Rossing MA |
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| Jazyk: | angličtina |
| Zdroj: | JAMA [JAMA] 1995 Jul 12; Vol. 274 (2), pp. 137-42. |
| Abstrakt: | Objective: To determine the risk of breast cancer in relation to the use of combined estrogen and progestin hormone replacement therapy (HRT). Design: A population-based case-control study. Setting: The general female population of King County in western Washington State. Participants: Middle-aged (50 to 64 years) women, including 537 patients with incident primary breast cancer diagnosed between January 1, 1988, and June 30, 1990, who were ascertained through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results cancer registry and 492 randomly selected control women without a history of breast cancer. Main Outcome Measure: Breast cancer risk in relation to use of menopausal hormones. Results: Menopausal hormones of some type had been used by 57.6% of breast cancer cases and 61.0% of comparison women. The women who had ever taken combined estrogen-progestin HRT, representing 21.5% of cases and 21.3% of controls, were not at increased risk of breast cancer (relative odds [RO] = 0.9; 95% confidence interval [CI], 0.7 to 1.3). Compared with nonusers of menopausal hormones, those who used estrogen-progestin HRT for 8 or more years had, if anything, a reduced risk of breast cancer (RO = 0.4; 95% CI, 0.2 to 1.0). Conclusions: On the whole, the use of estrogen with progestin HRT does not appear to be associated with an increased risk of breast cancer in middle-aged women. Nonetheless, since the use of combined estrogen-progestin HRT has only recently become prevalent, future investigations must assess whether breast cancer incidence is altered many years after estrogen-progestin HRT has been initiated, particularly among long-term users. |
| Databáze: | MEDLINE |
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