| Autor: |
Barbezat GO, Kaplan ER, Bowey FS, Berelowitz M, Van Hoorn-Hickman R |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 1979 Jan 15; Vol. 53 (3), pp. 255-9. |
| DOI: |
10.1016/0014-2999(79)90131-6 |
| Abstrakt: |
Dogs with gastric fistulae and denervated gastric pouches received graded doses of pentagastrin with and without a background infusion of somatostatin (1 microgram kg-1 h-1). Similarly, graded doses of somatostatin (0.25, 0.5, 1, 2 and 4 microgram kg-1 h-1) were infused after a steady state gastric secretion had been achieved with pentagastrin (1.5 microgram kg-1 h-1), about twice the dose required to produce half maximal (D50) response. Somatostatin inhibited pentagastrin-stimulated gastric acid secretion with competitive inhibition kinetics, but its precise site of action remains uncertain. The minimum effective dose of somatostatin on a twice D50 dose of pentagastrin was 0.25 microgram kg-1 h-1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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