| Autor: |
Agafonov VI, Dygaĭ AM, Boldyshev DA, Khlusov IA, Gol'dberg ED |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1995 Jul-Aug; Vol. 58 (4), pp. 41-4. |
| Abstrakt: |
The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.0 g and then received N-ANA. A rise in erythropoietic activity production by bone marrow cells testified that elevation of hemopoiesis inducing microenvironment function is the base of stimulating effect of N-ANA on hemopoiesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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