| Autor: |
Yang CW; Department of Internal Medicine, Catholic University Medical College, Seoul, Korea., Kim TG, Kim YS, Han H, Chang YS, Yoon YS, Bang BK |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of nephrology [Am J Nephrol] 1995; Vol. 15 (4), pp. 290-4. |
| DOI: |
10.1159/000168851 |
| Abstrakt: |
We measured the serum levels of soluble HLA class I antigen (sHLA-I) to evaluate the immune status of uremia and following renal transplantation. Twenty-one hemodialysis (HD) patients had serum samples collected for sHLA-I analysis before and after HD and also during the initial posttransplant period. The serum sHLA-I levels in patients undergoing HD were higher than in the normal controls (574.8 +/- 431.1 vs. 415.6 +/- 256.1 ng/ml, p < 0.05). In the HD patients, HD duration was not correlated with serum sHLA-I levels (r = 0.01, p > 0.05), and pre- and post-HD serum sHLA-I levels were not significantly different (574.8 +/- 431.1 vs. 568.3 +/- 398.4 ng/ml, p > 0.05). After successful renal transplantation, the serum sHLA-I levels decreased significantly (574.8 +/- 431.1 vs. 226.7 +/- 202.8 ng/ml, p = 0.0001) but increased significantly during the rejection period as compared to the prerejection period (642.8 +/- 296.1 vs. 305.5 +/- 194.7 ng/ml, p = 0.0002). In conclusion, sHLA-I levels are stable in uremic status and can be used as a parameter for monitoring acute graft rejection in renal transplantation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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