| Autor: |
Kuttan NA; School of Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Rosin MP, Ambika K, Priddy RW, Bhakthan NM, Zhang L |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of cancer. Part B, Oral oncology [Eur J Cancer B Oral Oncol] 1995 May; Vol. 31B (3), pp. 169-73. |
| DOI: |
10.1016/0964-1955(94)00051-5 |
| Abstrakt: |
A recent study reported a low prevalence of p53 expression (11%) in oral squamous cell carcinomas (SCCs) from South Asia, in contrast to a high prevalence (averaging 52%) in other studies. It was proposed that the different aetiologies for oral SCCs in the South Asia population, i.e. betel and tobacco chewing in combination with smoking and alcohol consumption as compared to smoking and alcohol consumption alone in other populations, may account for the low prevalence of p53 expression. To confirm this hypothesis, we examined p53 expression immunohistochemically in 23 cases of oral SCC from patients in Southern India. Thirteen of the 23 SCCs (56.5%) demonstrated nuclear p53 staining. The expression of p53 was strongly correlated with the number of tobacco-containing quids chewed per day (r = 0.8). These data support the hypothesis that carcinogens derived from tobacco and betel chewing may induce p53 mutations, which in turn are involved in the development of oral cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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