Composite graft survival. An auricular amputation model.
| Autor: | Henrich DE; Division of Otolaryngology Head and Neck Surgery, University of North Carolina, Chapel Hill, USA., Logan TC, Lewis RS, Shockley WW |
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| Jazyk: | angličtina |
| Zdroj: | Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 1995 Oct; Vol. 121 (10), pp. 1137-42. |
| DOI: | 10.1001/archotol.1995.01890100049008 |
| Abstrakt: | Objective: To study the effects of corticosteroids and fibroblast growth factor on composite graft survival using a rabbit model of auricular amputation and reimplantation. Design: Randomized, "blinded," placebo-controlled, prospective animal study. Setting: Animal laboratory in tertiary care center. Intervention: Amputation of the distal 2 cm of the rabbit ear as a composite graft and reimplantation with simple 6-0 prolene sutures. All animals underwent the same surgical procedure and were randomized into the following four groups: (1) surgical reimplantation alone; (2) 30 mg/kg intramuscular methylprednisolone sodium succinate for 5 days, starting immediately postoperatively; (3) topical basic fibroblast growth factor for 5 days postoperatively; and (4) delayed reimplantation with corticosteroids. In group 4, the ears of the animal were amputated, placed in iced saline containers for 90 minutes, and given 30 mg/kg intramuscular methylprednisolone for 5 days, with the first dose starting immediately prior to reimplantation. Main Outcome Measures: Percentage graft survival and histologic characteristics of viable and nonviable composite graft tissue. Results: The groups that received corticosteroids and delayed reimplantation with corticosteroids had a statistically significant increase in percentage of graft survival compared with the control group (P < .003 and P < .006, respectively). The growth factor group showed no significant difference from the control group. Conclusion: Neovascularization occurred in the viable grafts, thus suggesting its role in graft survival. This study establishes the efficacy of corticosteroids in enhancing composite graft survival. |
| Databáze: | MEDLINE |
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