| Autor: |
Warholm C; Karolinska Institute, Department of Medicine, Danderyd Hospital, Sweden., Wilczek H, Pettersson E |
| Jazyk: |
angličtina |
| Zdroj: |
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 1995; Vol. 8 (4), pp. 286-92. |
| DOI: |
10.1007/BF00346882 |
| Abstrakt: |
The incidence of hypertension 2 years after renal transplantation and the possible causes of hypertension were studied retrospectively. A group of 93 patients treated with cyclosporin (CyA), azathioprine (Aza), and/or prednisolone (Pred) were compared to a group of 31 patients treated with Aza and Pred. There were more patients with hypertension in the CyA group (73%) than in the Aza group (58%). Hypertension before transplantation predisposed to hypertension after transplantation. After transplantation, hypertension was most common among patients with polycystic kidney disease (46%), chronic glomerulonephritis (67%), and diabetes (71%). The accumulated immunosuppressive medication (CyA/Pred) did not affect the occurrence of hypertension. Hypertensive patients had significantly poorer graft function than did normotensive patients (serum creatinine level 229 mumol/l vs 162 mumol/l, P < 0.01). The 10-year graft survival was markedly impaired in the group with hypertension (42% vs 65% for normotensives, P < 0.05). The 10-year patient survival was 59% vs 79% (P = NS). The study further confirms the frequent finding that hypertension has a negative effect on graft and patient survival rates. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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