| Autor: |
Begara I; Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, UK., Lujan L, Hopkins J, Collie DD, Miller HR, Watt NJ |
| Jazyk: |
angličtina |
| Zdroj: |
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 1995 Apr; Vol. 45 (3-4), pp. 197-210. |
| DOI: |
10.1016/0165-2427(94)05354-u |
| Abstrakt: |
The stage of activation of bronchoalveolar lavage fluid (BALF) lymphocytes and peripheral blood lymphocytes (PBL) from maedi-visna virus (MVV) infected (n = 7) and control (n = 7) sheep was investigated by assessing four parameters of lymphocyte activation; lymphocyte size and complexity, loss of CD5+ T cells, expression of cell surface interleukin-2 receptor (IL-2R) and expression of DR and DQ MHC Class II molecules. BALF lymphocytes from MVV-infected animals had a significant loss of CD5+ lymphocytes (P < 0.05) and upregulation of DR and DQ MHC Class II molecules compared with controls, consistent with BALF lymphocyte activation. No changes in cell size and complexity or expression of IL-2R were observed. No evidence of PBL activation was detected. These findings suggest an impaired BALF lymphocyte activation during MVV infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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