Misplaced iron in kwashiorkor.
| Autor: | Dempster WS; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa., Sive AA, Rosseau S, Malan H, Heese HV |
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| Jazyk: | angličtina |
| Zdroj: | European journal of clinical nutrition [Eur J Clin Nutr] 1995 Mar; Vol. 49 (3), pp. 208-10. |
| Abstrakt: | Objectives: To determine the presence of radical promoting iron (non-protein-bound or loosely bound or free iron) in the plasma of children with kwashiorkor. Design: The bleomycin assay was employed for the quantitation of free or loosely bound iron. Setting: The Red Cross War Memorial Children's Hospital, Cape Town, Tertiary Care. Subjects: Fifty children on admission with kwashiorkor: six with marasmus and twelve healthy well-nourished controls. Results: Non-protein-bound iron was detected in the plasma of 58% of children with kwashiorkor but was absent in marasmic and healthy well-nourished children. Conclusions: The presence of radical promoting iron supports the hypothesis that a free radical injury probably plays a role in the pathogenesis of kwashiorkor and its removal may improve mortality. |
| Databáze: | MEDLINE |
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