Autor: |
Strieter RM; Department of Medicine, University of Michigan Medical School, Ann Arbor, USA., Kunkel SL, Arenberg DA, Burdick MD, Polverini PJ |
Jazyk: |
angličtina |
Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1995 May 05; Vol. 210 (1), pp. 51-7. |
DOI: |
10.1006/bbrc.1995.1626 |
Abstrakt: |
Angiogenesis is fundamental to a variety of physiological and pathological processes. While a number of factors have been identified that induce neovascularization, it is becoming increasingly apparent that endogenous angiostatic factors may play an important role in the regulation of angiogenesis during wound repair, chronic inflammation, and growth of solid tumors. In this study, we demonstrate the novel finding that IP-10, a member of the C-X-C chemokine family, is a potent inhibitor of both IL-8 and bFGF-induced angiogenic activity using in vitro and in vivo assays of angiogenesis. These findings support the contention that IP-10 may be a pivotal cytokine in the regulation of neovascularization. |
Databáze: |
MEDLINE |
Externí odkaz: |
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