| Autor: |
Tokarevich NK, Pogodina ON, Freĭdlin IS, Kuzina VA, Kramskaia TA, Artemenko NK |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 1994; Vol. 36 (11), pp. 1102-12. |
| Abstrakt: |
The immunogenicity of the Coxiella burnetii corpuscle antigen and two its components, obtained after the treatment with chloroform-methanol or extraction by trichloroacetic acid, was investigated. All the studied antigens were highly immunogenic. A strong correlation was discovered between the immunogenic and immunomodulating properties of the C. burnetii antigens. Cells of the mononuclear phagocytic system are the targets for stimulating action of the studied antigens. A cyclic increase of antibacterial activity and oxygen-dependent metabolism of the peritoneal cells was noted, in addition to the increase of the natural splenocyte cytotoxicity caused by the action of these antigens. The role of cytokines in rising the activity of peritoneal cells and splenocytes, caused by immunization of mice with the above antigenic substances, is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
