| Autor: |
Russo DC; L. F. Kimball Research Institute, New York Blood Center, NY 10021., Williams DJ, Grab DJ |
| Jazyk: |
angličtina |
| Zdroj: |
Parasitology research [Parasitol Res] 1994; Vol. 80 (6), pp. 487-92. |
| DOI: |
10.1007/BF00932695 |
| Abstrakt: |
Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37 degrees C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid elimination of complement-fixing VSG-antibody complexes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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