Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome.

Autor: Russell IJ; Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874., Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y, MacKillip F
Jazyk: angličtina
Zdroj: Arthritis and rheumatism [Arthritis Rheum] 1994 Nov; Vol. 37 (11), pp. 1593-601.
DOI: 10.1002/art.1780371106
Abstrakt: Objective: To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients.
Methods: CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radioimmunoassay. Clinical measures included tender point examination and standardized questionnaires.
Results: CSF SP levels were 3-fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination.
Conclusion: SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.
Databáze: MEDLINE
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