[The concept of biologic progression in metastatic cancer of the prostate hormonally treated].

Autor: Morote J; Servicio de Urología, Hospital General Universitario Vall d'Hebron, Barcelona., Lorente JA, Vallejo C, Encabo G, López-Pacios MA, De Torres JA, Soler Roselló A
Jazyk: Spanish; Castilian
Zdroj: Actas urologicas espanolas [Actas Urol Esp] 1994 Jun; Vol. 18 (6), pp. 666-9.
Abstrakt: A total of 110 patients with hormone-treated metastatic prostate cancer were monitored quarterly with serial PSA determinations. At the first control, 6 patients had progressed clinically, 5 of which had decreased PSA ranging between 9-77%. After a period of response, 69 patients progressed clinically, of which 1 showed no elevation of PSA levels, 14 showed progression concurrent with PSA increase, and 54 showed a period of gradual elevation of PSA over a range of 2-31 months. The probability of biological progression when the first rise occurred ranged between 72-96%, which after a second increase ranged between 92-100%, and all patients with three consecutive increases progressed clinically.
Databáze: MEDLINE