| Autor: |
Korsten MA; Alcohol Research Center, Bronx VA Medical Center, NY 10468., Długosz JW |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of pancreatology : official journal of the International Association of Pancreatology [Int J Pancreatol] 1993 Oct; Vol. 14 (2), pp. 149-55. |
| DOI: |
10.1007/BF02786121 |
| Abstrakt: |
The possible role of cathepsin B in the pathogenesis of two forms of acute pancreatitis was studied using the cathepsin B inhibitor known as E-64. In an edematous, nonfatal pancreatitis induced by supramaximal doses of cerulein, increases in the serum amylase and lipase levels were less pronounced in rats pretreated with E-64. Other parameters of pancreatic injury were unaffected by inhibition of cathepsin B. In a necrohemorrhagic type of pancreatic injury induced by retrograde infusion of bile salts into the pancreatic duct, E-64 partially attenuated increases in serum levels of amylase and lipase, and in addition, reduced the activation of trypsinogen. However, the high mortality in this model of pancreatitis was not modified. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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