| Autor: |
Odegaard OR; Sentrallaboratoriet, Aker sykehus, Oslo., Try K, Ly B, Gundersen T, Linnebo S |
| Jazyk: |
norština |
| Zdroj: |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 1993 Nov 20; Vol. 113 (28), pp. 3460-3. |
| Abstrakt: |
Protein S deficiency increases risk of thrombosis. At present, we have information on 63 Norwegian individuals with hereditary protein S deficiency belonging to 25 different families. 42 of the individuals have experienced at least one thromboembolic episode, and seven a cerebral infarction before the age of 70 years. The amount of free protein S in plasma is dependent on variation of the acute phase protein C4b-binding protein (C4bBP). Acute phase response with increased C4bBP induces free protein S deficiency, and increases risk of thrombosis. In patients with protein S deficiency, warfarin may reduce free protein S to critically low levels, and thus explain why, in some patients, recurrent thrombosis occurs during warfarin treatment. In this situation, warfarin should be replaced by heparin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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