Early involvement of central nervous system in type I diabetic patients.
| Autor: | Bax G; Department of Internal Medicine, Padova University, Padua, Italy., Lelli S, Grandis U, Cospite AM, Paolo N, Fedele D |
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| Jazyk: | angličtina |
| Zdroj: | Diabetes care [Diabetes Care] 1995 Apr; Vol. 18 (4), pp. 559-62. |
| DOI: | 10.2337/diacare.18.4.559 |
| Abstrakt: | Objective: To investigate whether the asymptomatic involvement of the central and peripheral nervous systems may be an early complication of diabetes. Research Design and Methods: We studied early impairment of the central and peripheral nervous system pathways in 15 type I diabetic patients with good metabolic control and short disease duration and in 10 healthy control subjects using a set of neurophysiological tests. Results: Results in diabetic subjects showed 1) impairment of motor (7% and somatosensory (13%) pathways of the central nervous system, 2) impairment of motor and sensory conduction velocities (40-60%), and 3) normal values of the vibration perception threshold and cardiovascular autonomic tests. Conclusions: The damage is more evident in peripheral sites where hyperglycemia and aldose reductase pathways are more active. Instead, several episodes of hypoglycemia, which occur in type I diabetic patients in good metabolic control, may cause alterations of brain nervous cells. |
| Databáze: | MEDLINE |
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