| Autor: |
Kamphuis JT; Department of Internal Medicine, Bosch Medicentrum, Location Grootziekengasthuis, NL's-Hertogenbosch, The Netherlands., Huider MC, Ras GJ, Verhagen CA, Kateman I, Vreeswijk JH, Burghouts JT |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1995; Vol. 37 (1-2), pp. 190-2. |
| DOI: |
10.1007/BF00685649 |
| Abstrakt: |
A total of 14 patients with platinum-resistant advanced epithelial ovarian cancer were treated with a continuous infusion of high-dose 5-fluorouracil (5-FU, 1200 mg/m2 per day) for 2 consecutive days weekly for 4 weeks and, thereafter, every 2 weeks in combination with a push injection of folinic acid (20 mg/m2) given just before 5-FU and after 24 h. No objective response was documented, and only five patients showed stable disease. The median survival was 6.5 months. There was minimal toxicity. This schedule of 5-FU in combination with folinic acid is not effective as second-line chemotherapy in advanced ovarian cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink