A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence.
| Autor: | Knoll LD; Center for Urological Treatment and Research, Nashville, Tennessee, USA., Benson RC Jr, Bilhartz DL, Minich PJ, Furlow WL |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of urology [J Urol] 1996 Jan; Vol. 155 (1), pp. 144-6. |
| DOI: | 10.1097/00005392-199601000-00055 |
| Abstrakt: | Purpose: We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction. Materials and Methods: A total of 20 patients diagnosed with arterial insufficiency and cavernous venous leakage by pharmacological penile duplex scanning underwent nonhormonal oral therapy. A randomized crossover study was performed using 5.4 mg. yohimbine plus 10 mg. isoxsuprine or 400 mg. pentoxifylline 3 times daily. Response to therapy was assessed by a sexual questionnaire and repeat penile duplex ultrasonography. Results: No patient in either phase of the study in either group had a complete response to the oral regimen(s) and there was no improvement in the pre-injection or post-injection cavernous arterial peak systolic flow velocities or resistance indexes. Conclusions: Our study suggests that these oral agents, although well tolerated, were not effective in the management of these patients with mixed vasculogenic erectile dysfunction. |
| Databáze: | MEDLINE |
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