Detection and monitoring of a concomitant atypical myeloproliferative disorder and chronic lymphocytic leukemia by flow-cytometric immunophenotyping.
| Autor: | McCoy JP Jr; Department of Pediatrics, Cooper Hospital-University Medical Center, UMDNJ-Robert Wood Johnson Medical School, Camden, USA., Johnson E, Catalano E, Blumstein L, Overton WR, Gryn J, Donaldson MH |
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| Jazyk: | angličtina |
| Zdroj: | Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 1995 Nov; Vol. 119 (11), pp. 1038-43. |
| Abstrakt: | Objective: To illustrate the utility of a broad panel of monoclonal antibodies to detect secondary processes or unexpected characteristics of the primary blood dyscrasia. Design: Case report and discussion. Setting: Regional academic medical center. Patient: A 64-year-old man presenting with an apparent acute myeloid leukemia. Interventions: Sequential immunophenotyping with a broad panel of monoclonal antibodies to monitor progression of disease and response to therapy. Main Outcome Measure: Identification and monitoring of the two atypical populations in this patient with correlation to the clinical status of the patient. Results: Identification of an unsuspected mature lymphoid clone and characterization of the evolution of the myelomonocytic clone. Conclusion: The evolving mature lymphoid clone may have been overlooked in the context of a predominant atypical myeloproliferative process, particularly if a limited panel of monoclonal antibodies had been used for immunophenotyping. Sequential immunophenotyping was useful in monitoring the progression of each atypical process. |
| Databáze: | MEDLINE |
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