An evaluation of prognostic scoring systems in patients with follicular thyroid cancer.

Autor: Davis NL; Department of Surgery, University of British Columbia, Vancouver Hospital and Health Sciences Center, Canada., Bugis SP, McGregor GI, Germann E
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 1995 Nov; Vol. 170 (5), pp. 476-80.
DOI: 10.1016/s0002-9610(99)80333-x
Abstrakt: Background: Prognostic scoring systems for thyroid cancer have not been investigated in patients with pure follicular cancer; thus, the purpose of this study was to compare the following prognostic indices: the European Organization for Research and Treatment of Cancer (EORTC) method; the Age, Grade, Extent, Size (AGES) score; and the Age, Metastasis, Extent, Size (ALIES) score.
Patients and Methods: A retrospective study reviewing 122 patients actively treated between 1955 and 1990 was conducted. Scoring systems were calculated and survival analysis completed. AGES low-risk patients were analyzed with respect to known risk factors.
Results: The AGES scoring system significantly defined low- and high-risk groups (P = 0.0041); the ratio of deaths between high-versus low-risk groups was 1.9:1. EORTC scores distinguished four risk groups (P = 0.002). The AMES scoring system did not significantly assign risk. In multivariate analysis of low-risk AGES patients, age, perithyroidal tissue involvement, and positive frozen section reached statistical significance.
Conclusions: The AGES and EORTC scoring systems best defined low- and high-risk groups of patients with pure follicular cancer, although the separation between groups was low.
Databáze: MEDLINE
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