[A trial of the use of sandostatin in patients with chronic pancreatitis].

Autor: Loginov AS, Sadokov VM, Vinokurova LV, Chernoiarova OD, Astaf'eva OV, Nilova TV
Jazyk: ruština
Zdroj: Terapevticheskii arkhiv [Ter Arkh] 1995; Vol. 67 (7), pp. 60-2.
Abstrakt: Out of 15 patients with chronic pancreatitis (CP) treated with sandostatin, 8 patients demonstrated a complete and 6 partial response. One patient did not respond. Pain relief occurred in all of them. Side effects were registered in 3 patients (doughy stools 4 times a day throughout treatment). Normal blood levels of pancreatic enzymes, insulin secretion, parameters of blood inhibitory system did not change much because of sandostatin administration, whereas hypercoagulation got diminished. Rat experiments have revealed a trend to trypsin lowering in tissues of unaffected pancreas and more intensive inhibition of active trypsin by tissue inhibitors.
Databáze: MEDLINE