| Autor: |
Wills RA, Southard WM, Sofer SS |
| Jazyk: |
angličtina |
| Zdroj: |
The International journal of artificial organs [Int J Artif Organs] 1980 Sep; Vol. 3 (5), pp. 293-7. |
| Abstrakt: |
Poly-L-lysine-succinyl-NADP, an analogue for nicotinamide adenine dinucleotide phosphate (NADP/H), has been synthesized by linking NADP/H to poly-L-lysine hydrobromide. This analogue (PL-SNP) was assayed with N, N dimethylaniline (DMA) in the presence of hepatic microsomal oxidase. A regeneration system of G-6-p and G-6-PD was used for reducing the PL-SNP+ to PL-SNPH. This reaction scheme with PL-SNP was found to exhibit up to 100% of the initial activity of pure NADP+ based on polarographic studies. Reaction rate of production for dimethylaniline oxide (DMA-0) was determined by oxygen consumption and by oxide formation. One of the potential uses of this analogue is as a cofactor in a membrane/liver enzyme detoxification system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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